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Savella (Milnacipran Hydrochloride) Tablets

Antidepressant Medicines, Depression and other serious Mental Illnesses, and Suicidal Thoughts or Actions

Milnacipran (Savella) is not used to treat depression, but it acts like medicines that are used to treat depression (antidepressants) and other psychiatric disorders.

Read the Medication Guide that comes with you or your family member's antidepressant medicine. This Medication Guide is only about the risk of suicidal thoughts or actions with antidepressant medicines. Talk to your or your family member's healthcare provider about:

  • all risks and benefits of treatment with antidepressant medicines
  • all treatment choices for depression or other serious mental illness

    What is the most important information I should know about antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions?

  • Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment.
  • How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member?
  • Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) bipolar illness (also called manic-depressive illness) or suicidal thoughts or actions.
  • Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
  • Keep all follow-up visits with the healthcare provider as scheduled. Call the doctor, pharmacist, or other healthcare professional between visits as needed, especially if you have concerns about symptoms.
  • Call the healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings.

    Call your physician or pharmacist right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:

  • thoughts about suicide or dying
  • attempts to commit suicide
  • new or worse irritability
  • acting aggressive, being angry, or violent
  • acting on dangerous impulses
  • new or worse depression
  • new or worse anxiety
  • feeling very agitated or restless (mania)
  • an extreme increase in activity and talking
  • panic attacks
  • trouble sleeping (insomnia)
  • other unusual changes in behavior or mood

    What else do I need to know about antidepressant medicines?

  • Never stop an antidepressant medicine without first talking to a doctor, pharmacist, or other healthcare provider. Stopping an antidepressant medicine suddenly can cause other symptoms.
  • Antidepressants are medicines used to treat depression and other illnesses. It is important to discuss all the risks of treating depression and also the risks of not treating it. Patients and their families or other caregivers should discuss all treatment choices with the healthcare provider, not just the use of antidepressants.
  • Antidepressant medicines have other side effects. Talk to the healthcare provider about the side effects of the medicine prescribed for you or your family member.
  • Antidepressant medicines can interact with other medicines. Know all of the medicines that you or your family member takes. Keep a list of all medicines to show the healthcare provider. Do not start new medicines without first checking with your healthcare provider.
  • Not all antidepressant medicines prescribed for children are FDA approved for use in children. Talk to your child's healthcare provider for more information. Call your doctor for medical advice about side effects.

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